In mass spectrometry, MS, the mass analyzer separates and measures the mass-to-charge ratio, m/z, of ions generated by the ion source. Using a mass analyzer with a customizable MS bench can help save space in your lab and produce accurate and reliable results. Here is more information about six different types of mass analyzers:
1. Time-of-Flight Mass Analyzers
The time-of-flight mass spectrometer, TOF-MS, is a popular mass analyzer. It measures the flight time of ions from the ion source to the detector. It subjects the ions to an electrical field that accelerates them toward the detector. The time it takes for the ions to reach the detector is directly proportional to their m/z ratio. One advantage of the TOF-MS is its high sensitivity and fast acquisition speed, making it suitable for high-throughput analysis. The TOF-MS is used in proteomics, metabolomics, and environmental analysis. Find an MS bench with power connections and surge suppressors to keep your time-of-flight mass analyzer near your workspace for efficient data recording.
2. Quadrupole Mass Analyzer
A quadrupole mass analyzer uses a set of four parallel rods to selectively transmit ions based on their m/z ratio. It applies varying electrical fields to the rods, creating a series of stable and unstable regions that filter the ions. The quadrupole mass analyzer is known for its high selectivity, speed, and versatility. It is commonly used in drug discovery and the analysis of foods and trace elements.
3. Ion Trap Mass Analyzer
The ion trap is a more complex mass analyzer that combines electric and magnetic fields to trap and isolate ions within a confined space. It works by simultaneously applying a strong radio frequency and a weak direct current to a set of electrodes, trapping the ions in the center. By varying the radio frequency and direct current fields, the ion trap can scan through a range of m/z ratios. This makes it useful for tandem mass spectrometry and structural elucidation of complex molecules. The ion trap mass analyzer is commonly used in proteomics, metabolomics, and lipidomics.
4. Fourier Transform Ion Cyclotron Resonance Mass Analyzer
The Fourier transform ion cyclotron resonance mass analyzer, FT-ICR, is one of the most advanced and powerful mass analyzers. It uses a combination of a superconducting magnet, ion trapping, and radiofrequency excitation to measure the m/z ratio of ions with high accuracy and resolution. The FT-ICR can help analyze large biomolecules and complex mixtures such as petroleum and natural products. It is also used in imaging mass spectrometry to map the spatial distribution of molecules in tissue sections.
5. Orbitrap Mass Analyzer
This relatively new device is used for high-resolution and accurate mass measurements. It works by trapping ions in an electrostatic field inside a circular trap. It then perturbs them to oscillate along the central axis. The frequency of the ion’s oscillations is proportional to its mass, which is measured to calculate its m/z ratio. The Orbitrap mass analyzer has exceptional resolution, sensitivity, and accuracy in mass determinations. It is helpful in proteomics research and in analyzing small molecules and proteins.
6. Magnetic Sector Mass Analyzer
This mass analyzer uses magnetic fields to deflect ions, separating them based on their mass-to-charge ratio. The magnetic sector device is one of the oldest mass analyzers, and it is still relevant today for organic and inorganic compound analysis, isotopic ratio determinations, and trace element analysis. Compared to other mass analyzers, the magnetic sector delivers high separation power and reproducibility, making it an excellent tool for precision measurements.
Find the Right MS Bench for Your Mass Analyzer
Mass analyzers play a significant role in the processes of mass spectrometry. With the various analyzer options, lab managers should find MS benches that meet their analyzer’s needs. MS benches can be customized with features like vacuum pumps, shock absorbers, pump enclosures, and more. Find the right MS bench for your lab today to save space and time during your research and experiments.
